Dr. Barks describes the pathophysiology of HIE, which forms the rationale for treatment of HIE with hypothermia, one of the great advances of neonatal neurology. He also relates knowledge gained from preclinical research to increase understanding of possible reasons for recent unsuccessful trials for HIE, and the rationale for the next generation of clinical trials for HIE currently in progress. Medical management of infants with HIE includes possible systemic complications of HIE and pharmacologic implications of both HIE and therapeutic hypothermia.
List eligibility and exclusion criteria for treatment with neonatal therapeutic hypothermia.
Describe the characteristics of cooling protocols that are known to be safe and effective, including transport cooling protocols.
Distinguish between side effects of neonatal therapeutic hypothermia and side effects of a multi-organ perinatal hypoxic-ischemic insult.
Describe modifications to established cooling protocols that failed to improve outcomes.
Professor of Pediatrics Director, Division of Neonatal-Perinatal Medicine,
The University of Michigan