In infants with hypoplastic left heart syndrome (HLHS), the left ventricle of the heart does not develop appropriately; the right side of the heart must perform “double duty,” pumping blood both to the lungs and to the body. This added work strains the heart and by adolescence the heart can begin to weaken and even fail, causing some children to require a heart transplant. By injecting the infant’s own stem cells into the right heart, the hope is that these cells will serve as a fertilizer to make new heart muscle cells so the heart does not weaken or fail. Dr. Subramanyan explores these new therapies.
Identify the limitations in current care for hypoplastic left heart syndrome (HLHS).
Describe the current regenerative approaches to HLHS.
Discuss clinical trials studying stem cells in HLHS.
Assistant Professor of Surgery and Pediatrics,
University of Southern California/Children's Hospital, Los Angeles